AFFOA, a Manufacturing USA Institute, addresses the spectrum of manufacturing challenges associated with developing and scaling advanced fibers and textiles from design through pilot production, helping to transition innovative technologies, and training the next generation manufacturing workforce. The institute’s Fabric Innovation Network (FIN) of member companies enables the development and commercialization of textile products that can see, hear, sense, communicate, store energy, regulate temperature, monitor health, and change color while delivering the conventional qualities of fabrics to benefit the commercial consumer and warfighter. The institute delivers breakthrough capabilities and innovations for national security through de-risking university technologies, non-traditional defense contractor participation, and the development of advanced textile systems. AFFOA centralizes the revolutionary fiber and fabric technology capabilities of startups, manufacturers, industry, and academia and organizes them to produce and manufacture advanced textile systems for the Department of Defense and commercial markets.

This draft guidance provides recommendations to persons and organizations interested in participating in FDA’s Advanced Manufacturing Technologies Designation Program, which is intended to facilitate the development of drugs, including biological products, manufactured using an AMT that has been designated as such under the program. 

The Advanced Materials & Manufacturing Technologies Office (AMMTO) supports a globally competitive U.S. manufacturing sector that accelerates the adoption of innovative materials and manufacturing technologies in support of a clean, decarbonized economy. AMMTO does this through their mission: to inspire people and drive innovation to transform materials and manufacturing for America's energy future.

The Advanced Research Projects Agency-Energy (ARPA-E) advances high-potential, high-impact energy technologies that are too early for private-sector investment. ARPA-E awardees are unique because they are developing entirely new ways to generate, store, and use energy.

The ARM Institute, a Manufacturing USA Institute, strengthens U.S. manufacturing through innovations in advanced manufacturing technology, particularly robotics and artificial intelligence (AI), and prepares the workforce to work alongside these technologies. We foster collaboration between those who can create and maintain robotics and those who can leverage it for maximum economic impact. Working across industry, government, and academia, we leverage a robust ecosystem to fulfill our vision and mission. The ARM Institute, with its national consortium and support from the U.S. Federal Government, empowers the full US manufacturing ecosystem. The ARM Institute bridges the gap between funding and impact, identifying problems and spurring solutions.

AIM Photonics, a Manufacturing USA Institute, offers start-ups, designers and developers, and academic researchers access to a supporting infrastructure of services across the entire silicon photonics development cycle: design, simulation, fabrication, packaging, validation, and a path to volume manufacturing. Their mission is to advance integrated photonic circuit manufacturing technology development in the United States.

America Makes is a national accelerator and the nation's leading collaborative partner for technology research, discovery, creation, and innovation in additive manufacturing and 3D printing.

The Bioenergy Technologies Office (BETO) within the U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) supports the research, development, and demonstration (RD&D) of technologies aimed at mobilizing domestic renewable carbon resources for the reduction of greenhouse gas (GHG) emissions across the U.S. economy. BETO funds work in collaboration with industry, academia, and DOE national laboratories to develop advanced technologies and innovative solutions to reduce the costs of biofuels. The R&D supported by BETO and its partners is creating cutting-edge technologies used in the processing of biomass and waste, from harvesting and preprocessing to conversion. BETO is focused on technologies to efficiently convert organic materials and biomass into affordable biofuels and bioproducts. 

BioFabUSA, a Manufacturing USA Institute and program of the Advanced Regenerative Manufacturing Institute (ARMI), is a public-private partnership including companies, academic institutions and not-for profit organizations. The mission of BioFabUSA is to bring together the fundamental tenets of good manufacturing processes and the science of regenerative medicine to create regenerative manufacturing and the trained and ready workforce necessary for that manufacturing.

BioMADE is building a sustainable, domestic, end-to-end bioindustrial manufacturing ecosystem.  BioMADE, a Manufacturing USA Institute, has the mission and flexibility to propel new biotechnology products from the laboratory to the commercial market.  In addition to supporting the development of technologies to strengthen American competitiveness, BioMADE is building the workforce of the future by partnering with K-12 schools, community colleges, universities, and professional development organizations. 

The Clean Energy Manufacturing Initiative is an effort across the Department of Energy in innovation and breaking down market barriers to enhance U.S. manufacturing competitiveness while advancing progress toward the nation’s energy goals. This site provides federal resources to help you design, scale up, and commercialize your technology.

The Clean Energy Smart Manufacturing Innovation Institute (CESMII), a Manufacturing USA Institute, focuses on the research and development of technologies and solutions that can capture, share, and process in real-time the increasing amounts of information available at manufacturing facilities. These technologies are expected to enable dramatically improved process control and operation, and enable benefits such as improved energy efficiency, equipment reliability, productivity gains, as well as related improvements in safety, quality, and yield in manufacturing processes. 

Concentrating solar-thermal power (CSP) technologies can be used to generate electricity by converting energy from sunlight to power a turbine, but the same basic technologies can also be used to deliver heat to a variety of industrial applications, like water desalination, enhanced oil recovery, food processing, chemical production, and mineral processing. The U.S. Department of Energy Solar Energy Technologies Office (SETO) supports CSP research and development projects that work to improve the performance, reduce the cost, and improve the lifetime and reliability of materials, components, subsystems, and integrated solutions for CSP technologies.

The Cybersecurity Manufacturing Innovation Institute (CyManII), a Manufacturing USA Institute, is an inclusive national research institute with major leading research universities in cybersecurity, smart and energy-efficient manufacturing, and deep expertise in research and development, supply chains, factory automation, and workforce development. Funded by the DOE, CyManII aggregates the most advanced research institutions in revolutionary manufacturing, securing automation and supply chains, workforce development, and cybersecurity. The research team brings to bear the most powerful expertise and infrastructure needed to ensure the digital transformation that will continue to propel the U.S. in innovative research in manufacturing for decades.

The Industrial Efficiency & Decarbonization Office (IEDO) accelerates the innovation and adoption of cost-effective technologies that eliminate industrial greenhouse gas emissions. IEDO provides planning, management, and direction necessary for a balanced national program of research, development, demonstration, technical assistance, and workforce development to drive energy, materials and production efficiency, and decarbonization across the industrial sector. 

The Institute for Advanced Composites Manufacturing Innovation (IACMI), a Manufacturing USA Institute, is a partnership of industry, academic and governmental organizations joining forces to benefit the nation’s energy and economic security. This is accomplished by bringing low-cost, energy-efficient advanced composites to commercial readiness through the collaborative and innovative work of our members. Researchers at IACMI are working to develop lower-cost, higher-speed, and more efficient manufacturing and recycling processes for advanced composite materials. 

LIFT, a Manufacturing USA Institute, is a nonprofit, public-private partnership between industry, academia, and government that supports our nation’s economy and enhances its national security by accelerating innovative advanced manufacturing technology and talent development. LIFT solves the manufacturing equation by connecting materials, processes, systems, and talent needed to drive American manufacturing into the future.

Advanced manufacturing technologies for both terrestrial and in-space purposes will make commercial and exploration missions more efficient and affordable. NASA is developing new materials with improved or combined properties, learning how to build infrastructure, and innovating manufacturing processes. 

The MEP National Network^TM is a unique public-private partnership that delivers comprehensive, proven solutions to U.S. manufacturers, fueling growth and advancing U.S. manufacturing.  The Network comprises the National Institute of Standards and Technology’s Manufacturing Extension Partnership, the 51 MEP Centers located in all 50 states and Puerto Rico, the MEP Advisory Board, MEP Center boards, and the Foundation for Manufacturing Excellence, as well as over 1,440 trusted advisors and experts at approximately 460 MEP service locations. MEP Centers tailor services ranging from process improvement and workforce development to specialized business practices, including supply chain integration and technology transfer. Centers connect manufacturers with government agencies, trade associations, universities, research laboratories, state and federal initiatives, and other resources.

MxD, a Manufacturing USA Institute, is where innovative manufacturers forge their futures. In partnership with DoD, MxD, a Manufacturing USA Institute, provides manufacturers with digital tools and expertise to begin building every part better than the last.  Institute members increase their productivity and win more business, powered by a workforce with the digital skills they need for a cybersecure industrial base. MxD also works with DoD manufacturers and contractors to assess and implement digital improvements throughout the industrial base.

Manufacturing USA was created in 2014 to secure U.S. global leadership in advanced manufacturing by connecting people, ideas, and technology. Manufacturing USA institutes convene business competitors, academic institutions, and other stakeholders to test applications of new technology, create new products, reduce cost and risk, and enable the manufacturing workforce with the skills of the future. Key initiatives include Future Manufacturing Supply Chains Manufacturing, Manufacturing Workforce Development, Advanced Manufacturing Technology Leadership, Covid 19 Manufacturing Recovery, and Clean Energy Manufacturing.

America Makes, a Manufacturing USA Institute, is the nation’s leading public-private partnership for additive manufacturing (AM) technology and education. America Makes members from industry, academia, government, and workforce and economic development organizations work together to accelerate AM adoption and the nation’s global manufacturing competitiveness, focused on three areas – developing AM technology, developing an AM workforce, and maintaining a collaborative AM ecosystem. 

The Biopharmaceutical Manufacturing Preparedness Consortium (BioMaP-Consortium) supports the Biomedical Advanced Research and Development Authority (BARDA) and is comprised of industry partners across the drug and vaccine manufacturing supply chain, including manufacturers of required raw materials and consumables, developers of innovative manufacturing technologies, and suppliers of fill finish services. This consortium seeks to expand the industrial and manufacturing base for medical countermeasures to include the requisite capabilities, flexibilities, and strategies to secure needed medical supplies to meet the nation’s public health preparedness and response requirements.

The National Nanotechnology Initiative (NNI) is a U.S. Government research and development (R&D) initiative. Over thirty Federal departments, independent agencies, and commissions work together toward the shared vision of a future in which the ability to understand and control matter at the nanoscale leads to ongoing revolutions in technology and industry that benefit society. The NNI enhances interagency coordination of nanotechnology R&D, supports a shared infrastructure, enables leveraging of resources while avoiding duplication, and establishes shared goals, priorities, and strategies that complement agency-specific missions and activities.

The National Network for Manufacturing Innovation (NNMI) is an interagency initiative made up of public/private partnerships devoted to manufacturing excellence. Under the NNMI, each institute will bring together innovative manufacturers, university engineering schools, community colleges, federal agencies, non-profits, and regional and state organizations to invest in unique, but industrially relevant, manufacturing technologies with broad applications. Federal NNMI partners include the Departments of Energy, Defense, and Commerce, as well as NASA and the National Science Foundation. 

NextFlex, a Manufacturing USA Institute, together with its members, recognizes that the Hybrid Electronics technology base presents critically important opportunities for U.S. manufacturing. NextFlex is addressing the need for a strong U.S. manufacturing base through these three key areas: Expanding the electronics manufacturing ecosystem, providing access to a technology hub for pilot-scale Manufacturing, and building the workforce of tomorrow.

The NIST Office of Advanced Manufacturing (OAM) serves as the headquarters for the interagency Advanced Manufacturing National Program Office to coordinate Manufacturing USA, a network of manufacturing innovation institutes across the country that brings together industry, academia, and the public sector to advance American manufacturing. OAM is also responsible for the NIST-sponsored manufacturing innovation institute, NIIMBL, and other NIST-funded awards to Manufacturing USA.

The Office of Energy Efficiency and Renewable Energy (EERE) is working to build a clean energy economy that benefits all Americans. EERE’s mission is to accelerate the research, development, demonstration, and deployment of technologies and solutions to equitably transition America to net-zero greenhouse gas emissions economy-wide

The Building Technologies Office (BTO) develops, demonstrates, and accelerates the adoption of cost-effective technologies, techniques, tools and services that enable high-performing, energy-efficient and demand-flexible residential and commercial buildings in both the new & existing buildings markets, in support of an equitable transition to a decarbonized energy system by 2050, starting with a decarbonized power sector by 2035. 

As a member of Manufacturing USA, PowerAmerica connects many of the world’s leading wide bandgap (WBG) semiconductor manufacturers and end-users with experts from research universities and government labs. PowerAmerica is a member-driven consortium of industry, academia, and national labs — managed by North Carolina State University and headquartered on its Centennial Campus — accelerating the commercialization of energy-efficient silicon carbide and gallium nitride power semiconductor chips and electronics.

The Rapid Advancement in Process Intensification Deployment (RAPID) Institute, a Manufacturing USA Institute, focuses on breakthrough technologies to dramatically improve the energy efficiency of novel manufacturing processes and enable the development of modular processes. RAPID leverages approaches to modular chemical process intensification (MCPI)—such as combining multiple process steps such as mixing, reaction, and separation into a single more complex and intensified process—with the goal of improving productivity and efficiency, cutting operating costs, and reducing waste.

The Clean Energy Manufacturing Innovation Institute for Reducing Embodied-energy And Decreasing Emissions (REMADE), a Manufacturing USA Institute, focuses on early stage applied research towards innovations that could dramatically reduce the energy required to manufacture key materials and improve overall manufacturing energy efficiency through increased material reuse, recycling, and remanufacturing. EMADE is the only national institute focused entirely on developing innovative technologies to accelerate the U.S.’s transition to a Circular Economy. In partnership with industry, academia, trade organizations, and national laboratories, REMADE enables early-stage applied research and development that will create jobs, dramatically reduce embodied energy and greenhouse gas emissions, and increase the supply and use of recycled materials.

The Solar Energy Technologies Office (SETO) accelerates the advancement and deployment of solar technology in support of an equitable transition to a decarbonized economy. 

The Department of Energy (DOE) Solid-State Lighting Program fosters U.S. scientific capabilities, leverages private funds, provides internationally trusted information, and drives innovation to create efficient and flexible lighting products that support health, productivity, and well-being. the Solid-State Lighting Program has acted as a catalyst, bringing together researchers, industry, universities, standards organizations, utilities, energy efficiency programs, building owners, lighting designers, and specifiers to drive SSL technology advances. The Energy Policy Act of 2005 (EPACT 2005) and the Energy Independence and Security Act of 2007 (EISA 2007) issued directives to the Secretary of Energy to carry out a Next Generation Lighting Initiative to support SSL research, development, demonstration, and commercial application activities. In order to effectively fulfill the directives in EPACT 2005 and EISA 2007, DOE developed a comprehensive national strategy to build collaborative efforts with lighting industry and research partners to guide SSL technology innovation. 

The Building Technologies Office (BTO) develops, demonstrates, and accelerates the adoption of cost-effective technologies, techniques, tools and services that enable high-performing, energy-efficient and demand-flexible residential and commercial buildings in both the new and existing buildings markets. Moving scientific discoveries from research and development (R&D) concepts to commercially viable and available products to transforming the market via broad adoption is imperative for America to meet its climate goals while growing our economy. Technology-to-market (T2M) activities are designed to accelerate innovative R&D concepts to become commercially viable and available products. These activities then dovetail with market transformation efforts. 

Business Programs provide financial backing and technical assistance to stimulate business creation and growth. The programs work through partnerships with public and private community based organizations and financial institutions to provide financial assistance, business development, and technical assistance to rural businesses. These programs help to provide capital, equipment, space, job training, and entrepreneurial skills that can help to start and/or grow a business.  Business Programs also support the creation and preservation of quality jobs in rural areas.

The Building Technologies Office (BTO) develops, demonstrates, and accelerates the adoption of cost-effective technologies, techniques, tools, and services that enable high-performing, energy-efficient, and demand-flexible residential and commercial buildings in both the new and existing buildings markets. Next-generation windows and building envelope technologies have substantial technical potential to reduce energy consumption in buildings. Activities in windows and building envelope focus on technologies such as highly insulating materials and systems, and methodologies and analysis tools for measurement and validation of building envelope performance, as well as market-enabling efforts such as the creation of an organization responsible for rating, certifying, and labeling fenestration attachment products to better inform consumers.